4HI3

Crystal structure of dimeric R298A mutant of SARS coronavirus main protease

Summary for 4HI3

• Entry DOI: 10.2210/pdb4hi3/pdb
• Descriptor: 3C-like proteinase (2 entities in total)
• Functional Keywords: chymotrypsin-like protein, protease, cytosol, hydrolase
• Biological source: SARS coronavirus
• Cellular location: Non-structural protein 3: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 4: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 6: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 7: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 8: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 9: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 10: Host cytoplasm, host perinuclear region (By similarity): P0C6U8
• Total number of polymer chains: 2
• Total formula weight: 69985.71

Authors

Wu, C.-G.,Chou, C.-Y. (deposition date: 2012-10-11, release date: 2013-05-01, Last modification date: 2023-09-20)

• Primary citation: Wu, C.G.,Cheng, S.C.,Chen, S.C.,Li, J.Y.,Fang, Y.H.,Chen, Y.H.,Chou, C.Y.; Mechanism for controlling the monomer-dimer conversion of SARS coronavirus main protease.; Acta Crystallogr.,Sect.D, 69:747-755, 2013; PubMed: 23633583; DOI: 10.1107/S0907444913001315

Experimental method

X-RAY DIFFRACTION (2.09 Å)