4HC1
Crystal structure of a loop deleted mutant of human MAdCAM-1 D1D2 complexed with Fab 10G3
Summary for 4HC1
Entry DOI | 10.2210/pdb4hc1/pdb |
Descriptor | Mucosal addressin cell adhesion molecule 1, 10G3 heavy chain, 10G3 light chain, ... (5 entities in total) |
Functional Keywords | immunoglobulin superfamily, rolling and firm adhesion, integrin alpha4beta7, immune system |
Biological source | Homo sapiens (human) More |
Cellular location | Membrane; Single-pass type I membrane protein: Q13477 |
Total number of polymer chains | 6 |
Total formula weight | 138358.87 |
Authors | Springer, T.,Yu, Y.,Zhu, J. (deposition date: 2012-09-28, release date: 2013-01-23, Last modification date: 2020-07-29) |
Primary citation | Springer, T.,Yu, Y.,Zhu, J.,Wang, J.-H.,Huang, P.-S. A Different Fold with an Integrin-Binding Loop Specialized for Flexibility in Mucosal Addressin Cell Adhesion Molecule-1 TO BE PUBLISHED, |
Experimental method | X-RAY DIFFRACTION (2.871 Å) |
Structure validation
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