4DZY

Crystal structure of branched-chain alpha-ketoacid dehydrogenase kinase/(S)-2-chloro-3-phenylpropanoic acid complex with ADP

Summary for 4DZY

Entry DOI	10.2210/pdb4dzy/pdb
Related	3TZ0 3TZ2 3TZ4 3TZ5 4H7Q 4H81 4H85
Descriptor	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (6 entities in total)
Functional Keywords	ghkl protein kinase, allosteric kinase inhibitor, branched-chain alpha-ketoacid, branched-chain amino acids, maple syrup urine disease, diabetes and obesity, bergerat nucleotide-binding fold, protein kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Rattus norvegicus (rat)
Total number of polymer chains	1
Total formula weight	48049.47
Authors	Tso, S.C.,Chuang, J.L.,Gui, W.J.,Wynn, R.M.,Li, J.,Chuang, D.T. (deposition date: 2012-03-01, release date: 2013-03-27, Last modification date: 2024-02-28)
Primary citation	Tso, S.C.,Qi, X.,Gui, W.J.,Chuang, J.L.,Morlock, L.K.,Wallace, A.L.,Ahmed, K.,Laxman, S.,Campeau, P.M.,Lee, B.H.,Hutson, S.M.,Tu, B.P.,Williams, N.S.,Tambar, U.K.,Wynn, R.M.,Chuang, D.T. Structure-based design and mechanisms of allosteric inhibitors for mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase. Proc.Natl.Acad.Sci.USA, 110:9728-9733, 2013 Cited by PubMed: 23716694 DOI: 10.1073/pnas.1303220110 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.101 Å)

Structure validation