4D37

Structure of bovine endothelial nitric oxide synthase heme domain in complex with N-{[(1R,2R)-2-(3-fluorophenyl)cyclopropyl]methyl}-2-[2-(1H-imidazol-1-yl) pyrimidin-4-yl]ethanamine

Summary for 4D37

Entry DOI	10.2210/pdb4d37/pdb
Related	4D2Y 4D2Z 4D30 4D31 4D32 4D33 4D34 4D35 4D36 4D38 4D39 4D3A 4D3B 4V3U 4V3V 4V3W 4V3X 4V3Y 4V3Z
Descriptor	NITRIC OXIDE SYNTHASE, ENDOTHELIAL, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (8 entities in total)
Functional Keywords	oxidoreductase, nitric oxide synthase, inhibitor complex
Biological source	BOS TAURUS (CATTLE)
Cellular location	Cell membrane : P29473
Total number of polymer chains	2
Total formula weight	102211.97
Authors	Li, H.,Poulos, T.L. (deposition date: 2014-10-20, release date: 2014-12-24, Last modification date: 2015-03-04)
Primary citation	Mukherjee, P.,Li, H.,Sevrioukova, I.,Chreifi, G.,Martasek, P.,Roman, L.J.,Poulos, T.L.,Silverman, R.B. Novel 2,4-Disubstituted Pyrimidines as Potent, Selective, and Cell-Permeable Inhibitors of Neuronal Nitric Oxide Synthase. J.Med.Chem., 58:1067-, 2015 Cited by PubMed: 25489882 DOI: 10.1021/JM501719E PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation