4CWP

Human HSP90 alpha N-terminal domain in complex with an Aminotriazoloquinazoline inhibitor

Summary for 4CWP

Entry DOI	10.2210/pdb4cwp/pdb
Related	4CWF 4CWN 4CWO 4CWQ 4CWR 4CWS 4CWT
Descriptor	HEAT SHOCK PROTEIN HSP 90-ALPHA, 5-(1,3-benzodioxol-5-ylmethyl)[1,2,4]triazolo[1,5-c]quinazolin-2-amine (3 entities in total)
Functional Keywords	chaperone
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Cytoplasm : P07900
Total number of polymer chains	1
Total formula weight	26130.25
Authors	Casale, E.,Amboldi, N.,Brasca, G.,Caronni, D.,Colombo, N.,Dalvit, C.,Felder, E.R.,Fogliatto, G.,Isacchi, A.,Mantegani, S.,Polucci, P.,Riceputi, L.,Sola, F.,Visco, C.,Zuccotto, F.,Casuscelli, F. (deposition date: 2014-04-03, release date: 2014-07-09, Last modification date: 2017-06-28)
Primary citation	Casale, E.,Amboldi, N.,Brasca, M.G.,Caronni, D.,Colombo, N.,Dalvit, C.,Felder, E.R.,Fogliatto, G.,Galvani, A.,Isacchi, A.,Polucci, P.,Riceputi, L.,Sola, F.,Visco, C.,Zuccotto, F.,Casuscelli, F. Fragment-Based Hit Discovery and Structure-Based Optimization of Aminotriazoloquinazolines as Novel Hsp90 Inhibitors. Bioorg.Med.Chem., 22:4135-, 2014 Cited by PubMed: 24980703 DOI: 10.1016/J.BMC.2014.05.056 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation