4CU0

Structure of bovine endothelial nitric oxide synthase heme domain in complex with (R)-6-(3-amino-2-(5-(2-(6-amino-4-methylpyridin-2-yl) ethyl)pyridin-3-yl)propyl)-4-methylpyridin-2-amine

Summary for 4CU0

Entry DOI	10.2210/pdb4cu0/pdb
Related	4CTP 4CTQ 4CTR 4CTT 4CTU 4CTV 4CTW 4CTX 4CTY 4CTZ 4CU1
Descriptor	NITRIC OXIDE SYNTHASE, ENDOTHELIAL, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (8 entities in total)
Functional Keywords	oxidoreductase, inhibitor complex
Biological source	BOS TAURUS (CATTLE)
Cellular location	Cell membrane: P29473
Total number of polymer chains	2
Total formula weight	102290.17
Authors	Chreifi, G.,Li, H.,Poulos, T.L. (deposition date: 2014-03-15, release date: 2014-05-07, Last modification date: 2014-06-04)
Primary citation	Kang, S.,Tang, W.,Li, H.,Chreifi, G.,Martasek, P.,Roman, L.J.,Poulos, T.L.,Silverman, R.B. Nitric Oxide Synthase Inhibitors that Interact with Both a Heme Propionate and Tetrahydrobiopterin Show High Isoform Selectivity. J.Med.Chem., 57:4382-, 2014 Cited by PubMed: 24758147 DOI: 10.1021/JM5004182 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.08 Å)

Structure validation