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4CRD

Creating novel F1 inhibitors through fragment based lead generation and structure aided drug design

Summary for 4CRD
Entry DOI10.2210/pdb4crd/pdb
Related4CR5 4CR9 4CRA 4CRB 4CRC 4CRE 4CRF 4CRG
DescriptorCOAGULATION FACTOR XI, Methyl N-[4-[5-chloro-2-[[3-[5-chloro-2-(tetrazol-1-yl)phenyl]propanoylamino]methyl]-1H-imidazol-4-yl]phenyl]carbamate, SULFATE ION, ... (4 entities in total)
Functional Keywordshydrolase
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationSecreted: P03951
Total number of polymer chains1
Total formula weight27557.93
Authors
Primary citationFjellstrom, O.,Akkaya, S.,Beisel, H.,Eriksson, P.,Erixon, K.,Gustafsson, D.,Jurva, U.,Kang, D.,Karis, D.,Knecht, W.,Nerme, V.,Nilsson, I.,Olsson, T.,Redzic, A.,Roth, R.,Sandmark, J.,Tigerstrom, A.,Oster, L.
Creating Novel Activated Factor Xi Inhibitors Through Fragment Based Lead Generation and Structure Aided Drug Design.
Plos One, 10:13705-, 2015
Cited by
PubMed: 25629509
DOI: 10.1371/JOURNAL.PONE.0113705
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.1 Å)
Structure validation

217705

數據於2024-03-27公開中

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