4BAY

Phosphomimetic mutant of LSD1-8a splicing variant in complex with CoREST

Summary for 4BAY

Entry DOI	10.2210/pdb4bay/pdb
Related	2COM 2H94 2IW5 2UXN 2UXX 2V1D 2X0L 2XAF 2XAG 2XAH 2XAJ 2XAQ 2XAS 2Y48
Descriptor	LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A, REST COREPRESSOR 1, FLAVIN-ADENINE DINUCLEOTIDE, ... (4 entities in total)
Functional Keywords	oxidoreductase, demethylase splicing chromatin
Biological source	HOMO SAPIENS (HUMAN) More
Total number of polymer chains	2
Total formula weight	92323.09
Authors	Toffolo, E.,Paganini, L.,Rusconi, F.,Tortorici, M.,Pilotto, S.,Verpelli, C.,Tedeschi, G.,Maffioli, E.,Sala, C.,Mattevi, A.,Battaglioli, E. (deposition date: 2012-09-17, release date: 2013-11-27, Last modification date: 2023-12-20)
Primary citation	Toffolo, E.,Rusconi, F.,Paganini, L.,Tortorici, M.,Pilotto, S.,Heise, C.,Verpelli, C.,Tedeschi, G.,Maffioli, E.,Sala, C.,Mattevi, A.,Battaglioli, E. Phosphorylation of Neuronal Lysine-Specific Demethylase 1Lsd1/Kdm1A Impairs Transcriptional Repression by Regulating Interaction with Corest and Histone Deacetylases Hdac1/2. J.Neurochem., 128:616-, 2014 Cited by PubMed: 24111946 DOI: 10.1111/JNC.12457 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.1 Å)

Structure validation