4B7B

Eg5-3

Summary for 4B7B

• Entry DOI: 10.2210/pdb4b7b/pdb
• Related: 1II6 1Q0B 1X88 1YRS 2FKY 2FL2 2FL6 2G1Q 2GM1 2UYI 2UYM 2WOG 2X2R 2X7C 2X7D 2X7E 2XAE 4A1Z 4A28 4A2T 4A50 4A51 4A5Y 4AP0 4AQV 4AQW 4AS7
• Descriptor: KINESIN-LIKE PROTEIN KIF11, ADENOSINE-5'-DIPHOSPHATE, CADMIUM ION, ... (7 entities in total)
• Functional Keywords: cell cycle
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Cytoplasm: P52732
• Total number of polymer chains: 1
• Total formula weight: 43436.63

Authors

Talapatra, S.K.,Kozielski, F. (deposition date: 2012-08-17, release date: 2013-07-31, Last modification date: 2023-12-20)

• Primary citation: Talapatra, S.K.,Anthony, N.G.,Mackay, S.P.,Kozielski, F.; The Mitotic Kinesin Eg5 Overcomes Inhibition to the Phase I/II Clinical Candidate Sb743921 by an Allosteric Resistance Mechanism.; J.Med.Chem., 56:6317-, 2013; PubMed: 23875972; DOI: 10.1021/JM4006274

Experimental method

X-RAY DIFFRACTION (2.5 Å)