4AQW

Model of human kinesin-5 motor domain (1II6, 3HQD) and mammalian tubulin heterodimer (1JFF) docked into the 9.5-angstrom cryo-EM map of microtubule-bound kinesin-5 motor domain in the rigor state.

Summary for 4AQW

• Entry DOI: 10.2210/pdb4aqw/pdb
• Related: 1II6 1JFF 1Q0B 1SA0 1SA1 1TVK 1X88 1YRS 1Z2B 2FKY 2FL2 2FL6 2G1Q 2GM1 2UYI 2UYM 2WBE 2WOG 2X2R 2X7C 2X7D 2X7E 2XAE 2XRP 4A1Z 4A28 4A2T 4A50 4A51 4A5Y 4AP0 4AQV
• EMDB information: 2077 2078 2079 2080 2081
• Descriptor: TUBULIN ALPHA-1D CHAIN, TUBULIN BETA-2B CHAIN, KINESIN-LIKE PROTEIN KIF11, ... (7 entities in total)
• Functional Keywords: motor protein, microtubule, mitosis, cancer
• Biological source: HOMO SAPIENS (HUMAN); More
• Cellular location: Cytoplasm, cytoskeleton : Q2HJ86 Q6B856; Cytoplasm : P52732
• Total number of polymer chains: 3
• Total formula weight: 143661.82

Authors

Goulet, A.,Behnke-Parks, W.M.,Sindelar, C.V.,Rosenfeld, S.S.,Moores, C.A. (deposition date: 2012-04-19, release date: 2012-11-21, Last modification date: 2017-08-30)

• Primary citation: Goulet, A.,Behnke-Parks, W.M.,Sindelar, C.V.,Major, J.,Rosenfeld, S.S.,Moores, C.; The Structural Basis of Force Generation by the Mitotic Motor Kinesin-5.; J.Biol.Chem., 287:44654-, 2012; PubMed: 23135273; DOI: 10.1074/JBC.M112.404228

Experimental method

ELECTRON MICROSCOPY (9.5 Å)