3ZJT

Ternary complex of E.coli leucyl-tRNA synthetase, tRNA(Leu)574 and the benzoxaborole AN3017 in the editing conformation

Summary for 3ZJT

• Entry DOI: 10.2210/pdb3zjt/pdb
• Related: 3ZJU 3ZJV
• Descriptor: LEUCYL-TRNA SYNTHETASE, TRNALEU5 UAA ISOACCEPTOR, MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: ligase-rna complex, nucleotide (atp) -binding, protein biosynthesis, class i aminoacyl-trna synthetase, aminoacyl trna synthetase, atp binding, editing synthetase, ligase/rna
• Biological source: ESCHERICHIA COLI; More
• Cellular location: Cytoplasm: P07813
• Total number of polymer chains: 2
• Total formula weight: 128147.76

Authors

Cusack, S.,Palencia, A.,Crepin, T.,Hernandez, V.,Akama, T.,Baker, S.J.,Bu, W.,Feng, L.,Freund, Y.R.,Liu, L.,Meewan, M.,Mohan, M.,Mao, W.,Rock, F.L.,Sexton, H.,Sheoran, A.,Zhang, Y.,Zhang, Y.,Zhou, Y.,Nieman, J.A.,Anugula, M.R.,Keramane, E.M.,Savariraj, K.,Reddy, D.S.,Sharma, R.,Subedi, R.,Singh, R.,OLeary, A.,Simon, N.L.,DeMarsh, P.L.,Mushtaq, S.,Warner, M.,Livermore, D.M.,Alley, M.R.K.,Plattner, J.J. (deposition date: 2013-01-18, release date: 2013-04-17, Last modification date: 2023-12-20)

• Primary citation: Hernandez, V.,Crepin, T.,Palencia, A.,Cusack, S.,Akama, T.,Baker, S.J.,Bu, W.,Feng, L.,Freund, Y.R.,Liu, L.,Meewan, M.,Mohan, M.,Mao, W.,Rock, F.L.,Sexton, H.,Sheoran, A.,Zhang, Y.,Zhang, Y.,Zhou, Y.,Nieman, J.A.,Anugula, M.R.,Keramane, E.M.,Savariraj, K.,Reddy, D.S.,Sharma, R.,Subedi, R.,Singh, R.,O'Leary, A.,Simon, N.L.,De Marsh, P.L.,Mushtaq, S.,Warner, M.,Livermore, D.M.,Alley, M.R.K.,Plattner, J.J.; Discovery of a Novel Class of Boron-Based Antibacterials with Activity Against Gram-Negative Bacteria.; Antimicrob.Agents Chemother., 57:1394-, 2013; PubMed: 23295920; DOI: 10.1128/AAC.02058-12

Experimental method

X-RAY DIFFRACTION (2.2 Å)