3WHA

Hsp90 alpha N-terminal domain in complex with a tricyclic inhibitor

Summary for 3WHA

• Entry DOI: 10.2210/pdb3wha/pdb
• Related: 3B28
• Descriptor: Heat shock protein HSP 90-alpha, GLYCEROL, 4-{[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-1,3,5-triazin-2-yl]sulfanyl}butanamide, ... (5 entities in total)
• Functional Keywords: chaperone, chaperone-chaperone inhibitor complex, chaperone/chaperone inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P07900
• Total number of polymer chains: 2
• Total formula weight: 52524.12

Authors

Fukami, T.A.,Ono, N. (deposition date: 2013-08-23, release date: 2014-01-29, Last modification date: 2023-11-08)

• Primary citation: Suda, A.,Kawasaki, K.,Komiyama, S.,Isshiki, Y.,Yoon, D.-O.,Kim, S.-J.,Na, Y.-J.,Hasegawa, K.,Fukami, T.A.,Sato, S.,Miura, T.,Ono, N.,Yamazaki, T.,Saitoh, R.,Shimma, N.,Shiratori, Y.,Tsukuda, T.; Design and synthesis of 2-amino-6-(1H,3H-benzo[de]isochromen-6-yl)-1,3,5-triazines as novel Hsp90 inhibitors; Bioorg.Med.Chem., 22:892-905, 2014; PubMed: 24369839; DOI: 10.1016/j.bmc.2013.11.036

Experimental method

X-RAY DIFFRACTION (1.3 Å)