3WCM

The complex structure of HsSQS wtih ligand, ER119884

Summary for 3WCM

• Entry DOI: 10.2210/pdb3wcm/pdb
• Related: 3WC9 3WCA 3WCB 3WCC 3WCD 3WCE 3WCF 3WCG 3WCH 3WCI 3WCJ 3WCL
• Descriptor: Squalene synthase, (3R)-3-{[2-benzyl-6-(3-methoxypropoxy)pyridin-3-yl]ethynyl}-1-azabicyclo[2.2.2]octan-3-ol (3 entities in total)
• Functional Keywords: isoprenoids, drug discovery, human squalene synthase, transferase, er119884
• Biological source: Homo sapiens (human)
• Cellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein: P37268
• Total number of polymer chains: 6
• Total formula weight: 250173.03

Authors

Shang, N.,Li, Q.,Ko, T.P.,Chan, H.C.,Huang, C.H.,Ren, F.,Zheng, Y.,Zhu, Z.,Chen, C.C.,Guo, R.T. (deposition date: 2013-05-28, release date: 2014-06-18, Last modification date: 2024-03-20)

• Primary citation: Shang, N.,Li, Q.,Ko, T.P.,Chan, H.C.,Li, J.,Zheng, Y.,Huang, C.H.,Ren, F.,Chen, C.C.,Zhu, Z.,Galizzi, M.,Li, Z.H.,Rodrigues-Poveda, C.A.,Gonzalez-Pacanowska, D.,Veiga-Santos, P.,de Carvalho, T.M.,de Souza, W.,Urbina, J.A.,Wang, A.H.,Docampo, R.,Li, K.,Liu, Y.L.,Oldfield, E.,Guo, R.T.; Squalene synthase as a target for Chagas disease therapeutics.; Plos Pathog., 10:e1004114-e1004114, 2014; PubMed: 24789335; DOI: 10.1371/journal.ppat.1004114

Experimental method

X-RAY DIFFRACTION (2.06 Å)