3V4V

crystal structure of a4b7 headpiece complexed with Fab ACT-1 and RO0505376

Summary for 3V4V

• Entry DOI: 10.2210/pdb3v4v/pdb
• Related: 3V4P
• Descriptor: Integrin alpha-4, N-(2,6-dichlorobenzoyl)-4-[1,6-dimethyl-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridin-3-yl]-L-phenylalanine, Integrin beta-7, ... (11 entities in total)
• Functional Keywords: cell adhesion, madcam-1, membrane
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 8
• Total formula weight: 342633.92

Authors

Yu, Y.,Zhu, J.,Springer, T.A. (deposition date: 2011-12-15, release date: 2012-01-11, Last modification date: 2020-07-29)

• Primary citation: Yu, Y.,Zhu, J.,Mi, L.Z.,Walz, T.,Sun, H.,Chen, J.,Springer, T.A.; Structural specializations of a4b7, an Integrin that Mediates Rolling Adhesion; J.Cell Biol., 196:131-146, 2012; PubMed: 22232704; DOI: 10.1083/jcb.201110023

Experimental method

X-RAY DIFFRACTION (3.1 Å)