3V07

Crystal structure of R-6'-Me-3'-fluoro hexitol nucleic acid

Summary for 3V07

• Entry DOI: 10.2210/pdb3v07/pdb
• Related: 3V06
• Descriptor: DNA (5'-D(*GP*CP*GP*TP*AP*(F6H)P*AP*CP*GP*C)-3') (2 entities in total)
• Functional Keywords: a-form dna, 3'-fluoro hexitol nucleic acid, fhna, r-6'-me-fhna, antisense oligonucleotides, dna
• Total number of polymer chains: 2
• Total formula weight: 6182.10

Authors

Pallan, P.S.,Egli, M. (deposition date: 2011-12-07, release date: 2012-02-08, Last modification date: 2023-09-13)

• Primary citation: Pallan, P.S.,Yu, J.,Allerson, C.R.,Swayze, E.E.,Seth, P.,Egli, M.; Insights from crystal structures into the opposite effects on RNA affinity caused by the s- and R-6'-methyl backbone modifications of 3'-fluoro hexitol nucleic Acid.; Biochemistry, 51:7-9, 2012; PubMed: 22229409; DOI: 10.1021/bi201810r

Experimental method

X-RAY DIFFRACTION (1.24 Å)