3UZS

Structure of the C13.28 RNA Aptamer Bound to the G Protein-Coupled Receptor Kinase 2-Heterotrimeric G Protein Beta 1 and Gamma 2 Subunit Complex

Summary for 3UZS

• Entry DOI: 10.2210/pdb3uzs/pdb
• Related: 1OMW 3UZT
• Descriptor: Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (5 entities in total)
• Functional Keywords: protein-rna complex, protein kinase fold, rgs homology domain, pleckstrin homology domain, beta propeller, g protein-coupled receptor phosphorylation, rna aptamer, carboxymethylation, geranylgeranylation, transferase-rna complex, transferase/rna
• Biological source: Bos taurus (bovine); More
• Cellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential): P63212
• Total number of polymer chains: 4
• Total formula weight: 134677.33

Authors

Tesmer, J.J.G.,Tesmer, V.M. (deposition date: 2011-12-07, release date: 2012-07-11, Last modification date: 2023-09-13)

• Primary citation: Tesmer, V.M.,Lennarz, S.,Mayer, G.,Tesmer, J.J.; Molecular mechanism for inhibition of g protein-coupled receptor kinase 2 by a selective RNA aptamer.; Structure, 20:1300-1309, 2012; PubMed: 22727813; DOI: 10.1016/j.str.2012.05.002

Experimental method

X-RAY DIFFRACTION (4.52 Å)