3UPX

Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1300

Summary for 3UPX

Entry DOI	10.2210/pdb3upx/pdb
Related	3UPZ 3UQF 3UQG 3V51 3V5P 3V5T
Descriptor	Calmodulin-domain protein kinase 1, [2-amino-1-(piperidin-4-ylmethyl)-1H-benzimidazol-6-yl](phenyl)methanone (3 entities in total)
Functional Keywords	serine/threonine protein kinase, transferase, calcium-binding, atp-binding, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Toxoplasma gondii
Total number of polymer chains	1
Total formula weight	55561.33
Authors	Merritt, E.A.,Larson, E.T. (deposition date: 2011-11-18, release date: 2012-03-14, Last modification date: 2024-02-28)
Primary citation	Larson, E.T.,Ojo, K.K.,Murphy, R.C.,Johnson, S.M.,Zhang, Z.,Kim, J.E.,Leibly, D.J.,Fox, A.M.,Reid, M.C.,Dale, E.J.,Perera, B.G.,Kim, J.,Hewitt, S.N.,Hol, W.G.,Verlinde, C.L.,Fan, E.,Van Voorhis, W.C.,Maly, D.J.,Merritt, E.A. Multiple Determinants for Selective Inhibition of Apicomplexan Calcium-Dependent Protein Kinase CDPK1. J.Med.Chem., 55:2803-2810, 2012 Cited by PubMed: 22369268 DOI: 10.1021/jm201725v PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.27 Å)

Structure validation