3UPP

Structure of penicillin-binding protein A from M. tuberculosis: ceftrixaone acyl-enzyme complex

Summary for 3UPP

• Entry DOI: 10.2210/pdb3upp/pdb
• Related: 3LO7 3UN7 3UPN 3UPO
• Descriptor: Penicillin-binding protein A, CEFOTAXIME, C3' cleaved, open, bound form (3 entities in total)
• Functional Keywords: transpeptidase, peptidoglycan, beta-lactam, penicillin-binding protein-antibiotic complex, penicillin-binding protein/antibiotic
• Biological source: Mycobacterium tuberculosis
• Total number of polymer chains: 2
• Total formula weight: 97723.84

Authors

Davies, C.,Fedorovich, A. (deposition date: 2011-11-18, release date: 2012-10-24, Last modification date: 2023-09-13)

• Primary citation: Fedarovich, A.,Nicholas, R.A.,Davies, C.; The role of the beta5-alpha11 loop in the active-site dynamics of acylated penicillin-binding protein A from Mycobacterium tuberculosis; J.Mol.Biol., 418:316-330, 2012; PubMed: 22365933; DOI: 10.1016/j.jmb.2012.02.021

Experimental method

X-RAY DIFFRACTION (2.4 Å)