3UOT

Crystal Structure of MDC1 FHA Domain in Complex with a Phosphorylated Peptide from the MDC1 N-terminus

Summary for 3UOT

• Entry DOI: 10.2210/pdb3uot/pdb
• Related: 3UN0
• Descriptor: Mediator of DNA damage checkpoint protein 1 (3 entities in total)
• Functional Keywords: fha domain, dna-damage, mdc1 dimerization, cell cycle
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus: Q14676 Q14676
• Total number of polymer chains: 4
• Total formula weight: 29831.31

Authors

Clapperton, J.A.,Lloyd, J.,Haire, L.F.,Li, J.,Smerdon, S.J. (deposition date: 2011-11-17, release date: 2011-12-28, Last modification date: 2012-07-18)

• Primary citation: Jungmichel, S.,Clapperton, J.A.,Lloyd, J.,Hari, F.J.,Spycher, C.,Pavic, L.,Li, J.,Haire, L.F.,Bonalli, M.,Larsen, D.H.,Lukas, C.,Lukas, J.,MacMillan, D.,Nielsen, M.L.,Stucki, M.,Smerdon, S.J.; The molecular basis of ATM-dependent dimerization of the Mdc1 DNA damage checkpoint mediator.; Nucleic Acids Res., 40:3913-3928, 2012; PubMed: 22234878; DOI: 10.1093/nar/gkr1300

Experimental method

X-RAY DIFFRACTION (1.8 Å)