3UON

Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist

Summary for 3UON

Entry DOI	10.2210/pdb3uon/pdb
Descriptor	Human M2 muscarinic acetylcholine, receptor T4 lysozyme fusion protein, (3R)-1-azabicyclo[2.2.2]oct-3-yl hydroxy(diphenyl)acetate, beta-D-glucopyranose, ... (5 entities in total)
Functional Keywords	g protein-coupled receptor, gpcr, acetylcholine receptor, signaling protein-antagonist complex, signaling protein/antagonist
Biological source	Homo sapiens More
Total number of polymer chains	1
Total formula weight	53283.02
Authors	Haga, K.,Kruse, A.C.,Asada, H.,Yurugi-Kobayashi, T.,Shiroishi, M.,Zhang, C.,Weis, W.I.,Okada, T.,Kobilka, B.K.,Haga, T.,Kobayashi, T. (deposition date: 2011-11-16, release date: 2012-02-01, Last modification date: 2023-09-13)
Primary citation	Haga, K.,Kruse, A.C.,Asada, H.,Yurugi-Kobayashi, T.,Shiroishi, M.,Zhang, C.,Weis, W.I.,Okada, T.,Kobilka, B.K.,Haga, T.,Kobayashi, T. Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist. Nature, 482:547-551, 2012 Cited by PubMed: 22278061 DOI: 10.1038/nature10753 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3 Å)

Structure validation