X-ray structure of the E2 domain of the human amyloid precursor protein (APP) in complex with zinc

Summary for 3UMI

Related3UMH 3UMK
DescriptorAmyloid beta A4 protein, ACETATE ION, ZINC ION, ... (5 entities in total)
Functional Keywordsmetal binding site, metal binding, cell surface, secretory pathway, metal binding protein
Biological sourceHomo sapiens (human)
Cellular locationMembrane; Single-pass type I membrane protein P05067
Total number of polymer chains1
Total molecular weight26086.14
Dahms, S.O.,Konnig, I.,Roeser, D.,Guhrs, K.H.,Than, M.E. (deposition date: 2011-11-13, release date: 2012-01-25, Last modification date: 2017-11-08)
Primary citation
Dahms, S.O.,Konnig, I.,Roeser, D.,Guhrs, K.H.,Mayer, M.C.,Kaden, D.,Multhaup, G.,Than, M.E.
Metal Binding Dictates Conformation and Function of the Amyloid Precursor Protein (APP) E2 Domain.
J.Mol.Biol., 416:438-452, 2012
PubMed: 22245578 (PDB entries with the same primary citation)
DOI: 10.1016/j.jmb.2011.12.057
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.229604.3%2.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-07-29