3TOP

Crystral Structure of the C-terminal Subunit of Human Maltase-Glucoamylase in Complex with Acarbose

Summary for 3TOP

• Entry DOI: 10.2210/pdb3top/pdb
• Related: 3TON
• Related PRD ID: PRD_900007
• Descriptor: Maltase-glucoamylase, intestinal, 4,6-dideoxy-4-{[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino}-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose (3 entities in total)
• Functional Keywords: membrane, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Apical cell membrane; Single-pass type II membrane protein: O43451
• Total number of polymer chains: 2
• Total formula weight: 208745.59

Authors

Shen, Y.,Qin, X.H.,Ren, L.M. (deposition date: 2011-09-06, release date: 2011-11-23, Last modification date: 2023-11-01)

• Primary citation: Ren, L.M.,Qin, X.H.,Cao, X.F.,Wang, L.L.,Bai, F.,Bai, G.,Shen, Y.; Structural insight into substrate specificity of human intestinal maltase-glucoamylase; Protein Cell, 2:827-836, 2011; PubMed: 22058037; DOI: 10.1007/s13238-011-1105-3

Experimental method

X-RAY DIFFRACTION (2.881 Å)