3TJV

Crystal structure of human granzyme H with a peptidyl substrate

Summary for 3TJV

• Entry DOI: 10.2210/pdb3tjv/pdb
• Related: 3TJU 3TK9
• Descriptor: Granzyme H, PTSYAGDDSG, SULFATE ION, ... (4 entities in total)
• Functional Keywords: serine protease, cytolysis, hydrolase substrate, hydrolase
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasmic granule: P20718
• Total number of polymer chains: 2
• Total formula weight: 26372.48

Authors

Wang, L.,Zhang, K.,Wu, L.,Tong, L.,Sun, F.,Fan, Z. (deposition date: 2011-08-25, release date: 2011-12-28, Last modification date: 2023-11-01)

• Primary citation: Wang, L.,Zhang, K.,Wu, L.,Liu, S.,Zhang, H.,Zhou, Q.,Tong, L.,Sun, F.,Fan, Z.; Structural insights into the substrate specificity of human granzyme H: the functional roles of a novel RKR motif; J.Immunol., 188:765-773, 2012; PubMed: 22156497; DOI: 10.4049/jimmunol.1101381

Experimental method

X-RAY DIFFRACTION (2.4 Å)