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3TI6

Crystal structure of 2009 pandemic H1N1 neuraminidase complexed with oseltamivir

Summary for 3TI6
Entry DOI10.2210/pdb3ti6/pdb
Related3NSS 3TI3 3TI4 3TI5 3TI8 3TIA 3TIB 3TIC
DescriptorNeuraminidase, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
Functional Keywords6-bladed beta-propeller, calcium binding, glycosylation, antiviral, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceInfluenza A virus
Total number of polymer chains2
Total formula weight88547.45
Authors
Vavricka, C.J.,Li, Q.,Wu, Y.,Qi, J.,Wang, M.,Liu, Y.,Gao, F.,Liu, J.,Feng, E.,He, J.,Wang, J.,Liu, H.,Jiang, H.,Gao, G.F. (deposition date: 2011-08-20, release date: 2011-11-23, Last modification date: 2023-11-01)
Primary citationVavricka, C.J.,Li, Q.,Wu, Y.,Qi, J.,Wang, M.,Liu, Y.,Gao, F.,Liu, J.,Feng, E.,He, J.,Wang, J.,Liu, H.,Jiang, H.,Gao, G.F.
Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition
Plos Pathog., 7:e1002249-e1002249, 2011
Cited by
PubMed: 22028647
DOI: 10.1371/journal.ppat.1002249
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.69 Å)
Structure validation

217705

數據於2024-03-27公開中

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