3T3R

Human Cytochrome P450 2A6 in complex with Pilocarpine

Summary for 3T3R

Entry DOI	10.2210/pdb3t3r/pdb
Related	1Z10 1Z11 2FDU 2FDV 2FDW 2FDY 2PG5 2PG6 2PG7 3EBS 3T3Q 3T3S 3T3Z
Descriptor	Cytochrome P450 2A6, PROTOPORPHYRIN IX CONTAINING FE, (3S,4R)-3-ethyl-4-[(1-methyl-1H-imidazol-5-yl)methyl]dihydrofuran-2(3H)-one, ... (4 entities in total)
Functional Keywords	cyp2a6, cytochrome p450 2a6, p450 2a6, heme protein, monooxygenase, drug metabolism, xenobiotic metabolism, endoplasmic reticulum, membrane, oxidoreductase
Biological source	Homo sapiens (human)
Cellular location	Endoplasmic reticulum membrane; Peripheral membrane protein: P11509
Total number of polymer chains	4
Total formula weight	221985.52
Authors	DeVore, N.M.,Scott, E.E. (deposition date: 2011-07-25, release date: 2011-12-07, Last modification date: 2023-09-13)
Primary citation	DeVore, N.M.,Meneely, K.M.,Bart, A.G.,Stephens, E.S.,Battaile, K.P.,Scott, E.E. Structural comparison of cytochromes P450 2A6, 2A13, and 2E1 with pilocarpine. Febs J., 279:1621-1631, 2012 Cited by PubMed: 22051186 DOI: 10.1111/j.1742-4658.2011.08412.x PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation