3SJX

X-ray structure of human glutamate carboxypeptidase II (the E424A inactive mutant) in complex with N-acetyl-aspartyl-methionine

Summary for 3SJX

• Entry DOI: 10.2210/pdb3sjx/pdb
• Related: 3SJE 3SJF 3SJG
• Related PRD ID: PRD_000799
• Descriptor: Glutamate carboxypeptidase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
• Functional Keywords: hydrolase, metallopeptidase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cell membrane; Single-pass type II membrane protein. Isoform PSMA': Cytoplasm: Q04609
• Total number of polymer chains: 1
• Total formula weight: 82574.78

Authors

Plechanovova, A.,Byun, Y.,Alquicer, G.,Skultetyova, L.,Mlcochova, P.,Nemcova, A.,Kim, H.,Navratil, M.,Mease, R.,Lubkowski, J.,Pomper, M.,Konvalinka, J.,Rulisek, L.,Barinka, C. (deposition date: 2011-06-22, release date: 2011-10-05, Last modification date: 2020-07-29)

• Primary citation: Plechanovova, A.,Byun, Y.,Alquicer, G.,Skultetyova, L.,Mlcochova, P.,Nemcova, A.,Kim, H.J.,Navratil, M.,Mease, R.,Lubkowski, J.,Pomper, M.,Konvalinka, J.,Rulisek, L.,Barinka, C.; Novel Substrate-Based Inhibitors of Human Glutamate Carboxypeptidase II with Enhanced Lipophilicity.; J.Med.Chem., 54:7535-7546, 2011; PubMed: 21923190; DOI: 10.1021/jm200807m

Experimental method

X-RAY DIFFRACTION (1.66 Å)