3ROV

Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus

Summary for 3ROV

• Entry DOI: 10.2210/pdb3rov/pdb
• Related: 1ZNJ
• Descriptor: Insulin, PHENOL, ZINC ION, ... (6 entities in total)
• Functional Keywords: zinc-binding site, long-acting insulin analog, receptor binding protein engineering, global health, insulin fibrillation, stabilizing, hormone
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted: P01308 P01308
• Total number of polymer chains: 12
• Total formula weight: 35840.61

Authors

Weiss, M.A.,Wan, Z.L.,Dodson, E.J.,Liu, M.,Xu, B.,Hua, Q.X.,Turkenburg, M.,Whittingham, J.,Nakagawa, S.H.,Huang, K.,Hu, S.Q.,Jia, W.H.,Wang, S.H.,Brange, J.,Whittaker, J.,Arvan, P.,Katsoyannis, P.G.,Dodson, G.G. (deposition date: 2011-04-26, release date: 2012-05-02, Last modification date: 2023-09-13)

• Primary citation: Weiss, M.A.,Wan, Z.L.,Dodson, E.J.,Liu, M.,Xu, B.,Hua, Q.X.,Turkenburg, M.,Whittingham, J.,Nakagawa, S.H.,Huang, K.,Hu, S.Q.,Jia, W.H.,Wang, S.H.,Brange, J.,Whittaker, J.,Arvan, P.,Katsoyannis, P.G.,Dodson, G.G.; Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus; To be Published,

Experimental method

X-RAY DIFFRACTION (2.3 Å)