3QZQ

Human enterovirus 71 3C protease mutant E71D in complex with rupintrivir

Summary for 3QZQ

• Entry DOI: 10.2210/pdb3qzq/pdb
• Related: 3OSY
• Descriptor: 3C protein, 4-{2-(4-FLUORO-BENZYL)-6-METHYL-5-[(5-METHYL-ISOXAZOLE-3-CARBONYL)-AMINO]-4-OXO-HEPTANOYLAMINO}-5-(2-OXO-PYRROLIDIN-3-YL)-PENTANOIC ACID ETHYL ESTER (3 entities in total)
• Functional Keywords: chymotrypsin-fold, beta-ribbon, hydrolysis, nucleus, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Human enterovirus 71
• Total number of polymer chains: 4
• Total formula weight: 84757.02

Authors

Wang, J.,Fan, T.,Yao, X.,Wu, Z.,Guo, L.,Lei, X.,Wang, J.,Wang, M.,Jin, Q.,Cui, S. (deposition date: 2011-03-07, release date: 2011-08-10, Last modification date: 2024-02-21)

• Primary citation: Wang, J.,Fan, T.,Yao, X.,Wu, Z.,Guo, L.,Lei, X.,Wang, J.,Wang, M.,Jin, Q.,Cui, S.; Crystal Structures of Enterovirus 71 3C Protease Complexed with Rupintrivir Reveal the Roles of Catalytically Important Residues.; J.Virol., 85:10021-10030, 2011; PubMed: 21813612; DOI: 10.1128/JVI.05107-11

Experimental method

X-RAY DIFFRACTION (1.7001 Å)