3QZQ

Human enterovirus 71 3C protease mutant E71D in complex with rupintrivir

3QZQ の概要

関連するPDBエントリー3OSY
分子名称3C protein, 4-{2-(4-FLUORO-BENZYL)-6-METHYL-5-[(5-METHYL-ISOXAZOLE-3-CARBONYL)-AMINO]-4-OXO-HEPTANOYLAMINO}-5-(2-OXO-PYRROLIDIN-3-YL)-PENTANOIC ACID ETHYL ESTER (3 entities in total)
機能のキーワードchymotrypsin-fold, beta-ribbon, hydrolysis, nucleus, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
由来する生物種Human enterovirus 71
ポリマー鎖数4
分子量合計84757.02
構造登録者
Wang, J.,Fan, T.,Yao, X.,Wu, Z.,Guo, L.,Lei, X.,Wang, J.,Wang, M.,Jin, Q.,Cui, S. (登録日: 2011-03-07, 公開日: 2011-08-10, 最終更新日: 2015-05-06)
主引用文献
Wang, J.,Fan, T.,Yao, X.,Wu, Z.,Guo, L.,Lei, X.,Wang, J.,Wang, M.,Jin, Q.,Cui, S.
Crystal Structures of Enterovirus 71 3C Protease Complexed with Rupintrivir Reveal the Roles of Catalytically Important Residues.
J.Virol., 85:10021-10030, 2011
PubMed: 21813612 (主引用文献が同じPDBエントリー)
DOI: 10.1128/JVI.05107-11
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (1.7001 Å)
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構造検証レポート

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.248100.1%3.8%7.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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