3QAK

Agonist bound structure of the human adenosine A2a receptor

Summary for 3QAK

• Entry DOI: 10.2210/pdb3qak/pdb
• Related: 3eml
• Descriptor: Adenosine receptor A2a,lysozyme chimera, 6-(2,2-diphenylethylamino)-9-[(2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxy-oxolan-2-yl]-N-[2-[(1-pyridin-2-ylpiperidin-4-yl)carbamoylamino]ethyl]purine-2-carboxamide, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ... (4 entities in total)
• Functional Keywords: structural genomics, protein structure initiative, joint center for innovative membrane protein technologies, jcimpt, membrane protein, receptor, gpcr network, gpcr, signaling protein, hydrolase, psi-biology
• Biological source: Homo Sapien; More
• Cellular location: Cell membrane; Multi-pass membrane protein: P29274
• Total number of polymer chains: 1
• Total formula weight: 56230.72

Authors

Xu, F.,Wu, H.,Katritch, V.,Han, G.W.,Cherezov, V.,Stevens, R.,GPCR Network (GPCR) (deposition date: 2011-01-11, release date: 2011-03-09, Last modification date: 2018-01-24)

• Primary citation: Xu, F.,Wu, H.,Katritch, V.,Han, G.W.,Jacobson, K.A.,Gao, Z.G.,Cherezov, V.,Stevens, R.C.; Structure of an agonist-bound human A2A adenosine receptor.; Science, 332:322-327, 2011; PubMed: 21393508; DOI: 10.1126/science.1202793

Experimental method

X-RAY DIFFRACTION (2.71 Å)