3Q3K

Factor Xa in complex with a phenylenediamine derivative

Summary for 3Q3K

• Entry DOI: 10.2210/pdb3q3k/pdb
• Related: 1V3X 1WU1 2EI6 2EI7 2EI8 3IIT
• Descriptor: Activated factor Xa heavy chain, Factor X light chain, CALCIUM ION, ... (5 entities in total)
• Functional Keywords: protein inhibitor complex, blood coaggulation, cleavage of basic residues, disulfide bond, egf-like domain, hydroxylation, protease, secreted, zymogen, glycoprotein, hydrolase, blood coaggulation factor, serine protease, gamma-carboxyglutamic acid, plasma, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted: P00742 P00742
• Total number of polymer chains: 2
• Total formula weight: 32739.64

Authors

Suzuki, M.,Imai, E. (deposition date: 2010-12-22, release date: 2011-12-28, Last modification date: 2023-11-01)

• Primary citation: Yoshikawa, K.,Yoshino, T.,Yokomizo, Y.,Uoto, K.,Naito, H.,Kawakami, K.,Mochizuki, A.,Nagata, T.,Suzuki, M.,Kanno, H.,Takemura, M.,Ohta, T.; Design, synthesis and SAR of novel ethylenediamine and phenylenediamine derivatives as factor Xa inhibitors.; Bioorg.Med.Chem.Lett., 21:2133-2140, 2011; PubMed: 21345673; DOI: 10.1016/j.bmcl.2011.01.132

Experimental method

X-RAY DIFFRACTION (2 Å)