3PPJ

Human B-Raf Kinase in Complex with a Furopyridine Inhibitor

Summary for 3PPJ

Entry DOI	10.2210/pdb3ppj/pdb
Related	3PPK 3PRF 3PRI
Descriptor	Serine/threonine-protein kinase B-raf, methyl 3-{[(5S)-1-(hydroxyamino)-5H-inden-5-yl]amino}furo[2,3-c]pyridine-2-carboxylate (2 entities in total)
Functional Keywords	protein kinase, atp-competitive inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Nucleus (By similarity): P15056
Total number of polymer chains	2
Total formula weight	71109.92
Authors	Voegtli, W.C.,Vigers, G.P.A.,Morales, T.,Brandhuber, B.J. (deposition date: 2010-11-24, release date: 2011-02-02, Last modification date: 2024-02-21)
Primary citation	Ren, L.,Wenglowsky, S.,Miknis, G.,Rast, B.,Buckmelter, A.J.,Ely, R.J.,Schlachter, S.,Laird, E.R.,Randolph, N.,Callejo, M.,Martinson, M.,Galbraith, S.,Brandhuber, B.J.,Vigers, G.,Morales, T.,Voegtli, W.C.,Lyssikatos, J. Non-oxime inhibitors of B-Raf(V600E) kinase. Bioorg.Med.Chem.Lett., 21:1243-1247, 2011 Cited by PubMed: 21251822 DOI: 10.1016/j.bmcl.2010.12.061 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.7 Å)

Structure validation