3PHV
X-RAY ANALYSIS OF HIV-1 PROTEINASE AT 2.7 ANGSTROMS RESOLUTION CONFIRMS STRUCTURAL HOMOLOGY AMONG RETROVIRAL ENZYMES
Summary for 3PHV
Entry DOI | 10.2210/pdb3phv/pdb |
Descriptor | UNLIGANDED HIV-1 PROTEASE (1 entity in total) |
Functional Keywords | hydrolase, aspartic proteinase |
Biological source | HIV-1 M:B_HXB2R |
Cellular location | Gag-Pol polyprotein: Host cell membrane; Lipid-anchor . Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P04585 |
Total number of polymer chains | 1 |
Total formula weight | 10803.76 |
Authors | Lapatto, R.,Blundell, T.L.,Hemmings, A.,Wilderspin, A.,Wood, S.P.,Danley, D.E.,Geoghegan, K.F.,Hawrylik, S.J.,Hobart, P.M. (deposition date: 1991-11-04, release date: 1992-01-15, Last modification date: 2024-02-21) |
Primary citation | Lapatto, R.,Blundell, T.,Hemmings, A.,Overington, J.,Wilderspin, A.,Wood, S.,Merson, J.R.,Whittle, P.J.,Danley, D.E.,Geoghegan, K.F.,Hawrylik, S.J.,Lee, S.E.,Scheld, K.G.,Hobart, P.M. X-ray analysis of HIV-1 proteinase at 2.7 A resolution confirms structural homology among retroviral enzymes. Nature, 342:299-302, 1989 Cited by PubMed: 2682266DOI: 10.1038/342299a0 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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