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3PE6

Crystal Structure of a soluble form of human MGLL in complex with an inhibitor

Summary for 3PE6
Entry DOI10.2210/pdb3pe6/pdb
Related3HJU 3JW8 3JWE
DescriptorMonoglyceride lipase, (2-cyclohexyl-1,3-benzoxazol-6-yl){3-[4-(pyrimidin-2-yl)piperazin-1-yl]azetidin-1-yl}methanone (3 entities in total)
Functional Keywordsalpha-beta hydrolase fold, lipase, 2-arachidonyl-glycerol, membrane associated, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total formula weight33637.67
Authors
Schubert, C.,Schalk-Hih, C. (deposition date: 2010-10-25, release date: 2011-03-02, Last modification date: 2023-09-06)
Primary citationSchalk-Hihi, C.,Schubert, C.,Alexander, R.,Bayoumy, S.,Clemente, J.C.,Deckman, I.,DesJarlais, R.L.,Dzordzorme, K.C.,Flores, C.M.,Grasberger, B.,Kranz, J.K.,Lewandowski, F.,Liu, L.,Ma, H.,Maguire, D.,Macielag, M.J.,McDonnell, M.E.,Mezzasalma Haarlander, T.,Miller, R.,Milligan, C.,Reynolds, C.,Kuo, L.C.
Crystal structure of a soluble form of human monoglyceride lipase in complex with an inhibitor at 1.35 A resolution.
Protein Sci., 20:670-683, 2011
Cited by
PubMed: 21308848
DOI: 10.1002/pro.596
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.35 Å)
Structure validation

217705

數據於2024-03-27公開中

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