3P0G
Structure of a nanobody-stabilized active state of the beta2 adrenoceptor
Summary for 3P0G
Entry DOI | 10.2210/pdb3p0g/pdb |
Descriptor | Beta-2 adrenergic receptor, Lysozyme, Camelid Antibody Fragment, 8-[(1R)-2-{[1,1-dimethyl-2-(2-methylphenyl)ethyl]amino}-1-hydroxyethyl]-5-hydroxy-2H-1,4-benzoxazin-3(4H)-one (3 entities in total) |
Functional Keywords | beta-2 adrenoceptor, agonist, nanobody, 7tm, gpcr, membrane, signaling protein, hydrolase, membrane protein |
Biological source | Homo sapiens (human, Bacteriophage T4) More |
Cellular location | Cell membrane ; Multi- pass membrane protein : P07550 |
Total number of polymer chains | 2 |
Total formula weight | 70871.15 |
Authors | Rasmussen, S.G.F.,Choi, H.-J.,Fung, J.J.,Pardon, E.,Casarosa, P.,Chae, P.S.,DeVree, B.T.,Rosenbaum, D.M.,Thian, F.S.,Kobilka, T.S.,Schnapp, A.,Konetzki, I.,Sunahara, R.K.,Gellman, S.H.,Pautsch, A.,Steyaert, J.,Weis, W.I.,Kobilka, B.K. (deposition date: 2010-09-28, release date: 2011-01-19, Last modification date: 2023-09-06) |
Primary citation | Rasmussen, S.G.,Choi, H.J.,Fung, J.J.,Pardon, E.,Casarosa, P.,Chae, P.S.,Devree, B.T.,Rosenbaum, D.M.,Thian, F.S.,Kobilka, T.S.,Schnapp, A.,Konetzki, I.,Sunahara, R.K.,Gellman, S.H.,Pautsch, A.,Steyaert, J.,Weis, W.I.,Kobilka, B.K. Structure of a nanobody-stabilized active state of the b2 adrenoceptor Nature, 469:175-180, 2011 Cited by PubMed: 21228869DOI: 10.1038/nature09648 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.5 Å) |
Structure validation
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