3P0G

Structure of a nanobody-stabilized active state of the beta2 adrenoceptor

Summary for 3P0G

• Entry DOI: 10.2210/pdb3p0g/pdb
• Descriptor: Beta-2 adrenergic receptor, Lysozyme, Camelid Antibody Fragment, 8-[(1R)-2-{[1,1-dimethyl-2-(2-methylphenyl)ethyl]amino}-1-hydroxyethyl]-5-hydroxy-2H-1,4-benzoxazin-3(4H)-one (3 entities in total)
• Functional Keywords: beta-2 adrenoceptor, agonist, nanobody, 7tm, gpcr, membrane, signaling protein, hydrolase, membrane protein
• Biological source: Homo sapiens (human, Bacteriophage T4); More
• Cellular location: Cell membrane ; Multi- pass membrane protein : P07550
• Total number of polymer chains: 2
• Total formula weight: 70871.15

Authors

Rasmussen, S.G.F.,Choi, H.-J.,Fung, J.J.,Pardon, E.,Casarosa, P.,Chae, P.S.,DeVree, B.T.,Rosenbaum, D.M.,Thian, F.S.,Kobilka, T.S.,Schnapp, A.,Konetzki, I.,Sunahara, R.K.,Gellman, S.H.,Pautsch, A.,Steyaert, J.,Weis, W.I.,Kobilka, B.K. (deposition date: 2010-09-28, release date: 2011-01-19, Last modification date: 2023-09-06)

• Primary citation: Rasmussen, S.G.,Choi, H.J.,Fung, J.J.,Pardon, E.,Casarosa, P.,Chae, P.S.,Devree, B.T.,Rosenbaum, D.M.,Thian, F.S.,Kobilka, T.S.,Schnapp, A.,Konetzki, I.,Sunahara, R.K.,Gellman, S.H.,Pautsch, A.,Steyaert, J.,Weis, W.I.,Kobilka, B.K.; Structure of a nanobody-stabilized active state of the b2 adrenoceptor; Nature, 469:175-180, 2011; PubMed: 21228869; DOI: 10.1038/nature09648

Experimental method

X-RAY DIFFRACTION (3.5 Å)