3P0G

Structure of a nanobody-stabilized active state of the beta2 adrenoceptor

3P0G の概要

• エントリーDOI: 10.2210/pdb3p0g/pdb
• 分子名称: Beta-2 adrenergic receptor, Lysozyme, Camelid Antibody Fragment, 8-[(1R)-2-{[1,1-dimethyl-2-(2-methylphenyl)ethyl]amino}-1-hydroxyethyl]-5-hydroxy-2H-1,4-benzoxazin-3(4H)-one (3 entities in total)
• 機能のキーワード: beta-2 adrenoceptor, agonist, nanobody, 7tm, gpcr, membrane, signaling protein, hydrolase, membrane protein
• 由来する生物種: Homo sapiens (human, Bacteriophage T4); 詳細
• 細胞内の位置: Cell membrane ; Multi- pass membrane protein : P07550
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 70871.15

構造登録者

Rasmussen, S.G.F.,Choi, H.-J.,Fung, J.J.,Pardon, E.,Casarosa, P.,Chae, P.S.,DeVree, B.T.,Rosenbaum, D.M.,Thian, F.S.,Kobilka, T.S.,Schnapp, A.,Konetzki, I.,Sunahara, R.K.,Gellman, S.H.,Pautsch, A.,Steyaert, J.,Weis, W.I.,Kobilka, B.K. (登録日: 2010-09-28, 公開日: 2011-01-19, 最終更新日: 2023-09-06)

• 主引用文献: Rasmussen, S.G.,Choi, H.J.,Fung, J.J.,Pardon, E.,Casarosa, P.,Chae, P.S.,Devree, B.T.,Rosenbaum, D.M.,Thian, F.S.,Kobilka, T.S.,Schnapp, A.,Konetzki, I.,Sunahara, R.K.,Gellman, S.H.,Pautsch, A.,Steyaert, J.,Weis, W.I.,Kobilka, B.K.; Structure of a nanobody-stabilized active state of the b2 adrenoceptor; Nature, 469:175-180, 2011; PubMed: 21228869; DOI: 10.1038/nature09648

実験手法

X-RAY DIFFRACTION (3.5 Å)