3OYA

Crystal structure of the Prototype Foamy Virus (PFV) intasome in complex with magnesium and raltegravir at 2.65 resolution

「3L2T」から置き換えられました

3OYA の概要

• エントリーDOI: 10.2210/pdb3oya/pdb
• 関連するPDBエントリー: 3DLR 3L2Q 3L2R 3L2U 3L2V 3L2W 3OY9 3OYB 3OYC 3OYD 3OYE 3OYF 3OYG 3OYH 3OYI 3OYJ 3OYK 3OYL 3OYM 3OYN
• 分子名称: PFV integrase, DNA (5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP*TP*CP*GP*CP*A)-3'), DNA (5'-D(*TP*GP*CP*GP*AP*AP*AP*TP*TP*CP*CP*AP*TP*GP*AP*CP*A)-3'), ... (10 entities in total)
• 機能のキーワード: protein-dna complex, tetramer, dna integration, endonuclease, metal-binding, multifunctional enzyme, nuclease, nucleotidyltransferase, nucleus, transferase, viral nucleoprotein, virion, dna-binding, zinc binding, hhcc motif, viral protein, recombination, inhibitor, dna-binding protein-dna complex, viral protein-dna complex, viral protein/dna
• 由来する生物種: Human spumaretrovirus (SFVcpz(hu)); 詳細
• 細胞内の位置: Integrase: Virion (Potential). Protease/Reverse transcriptase/ribonuclease H: Host nucleus (By similarity): P14350
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 101104.86

構造登録者

Hare, S.,Cherepanov, P. (登録日: 2010-09-23, 公開日: 2010-10-20, 最終更新日: 2023-09-06)

• 主引用文献: Hare, S.,Vos, A.M.,Clayton, R.F.,Thuring, J.W.,Cummings, M.D.,Cherepanov, P.; Molecular mechanisms of retroviral integrase inhibition and the evolution of viral resistance.; Proc.Natl.Acad.Sci.USA, 107:20057-20062, 2010; PubMed: 21030679; DOI: 10.1073/pnas.1010246107

実験手法

X-RAY DIFFRACTION (2.65 Å)