3OMV

Crystal structure of c-raf (raf-1)

Replaces:  3LB7

Summary for 3OMV

• Entry DOI: 10.2210/pdb3omv/pdb
• Related: 3D4Q
• Descriptor: RAF proto-oncogene serine/threonine-protein kinase, (1E)-5-(1-piperidin-4-yl-3-pyridin-4-yl-1H-pyrazol-4-yl)-2,3-dihydro-1H-inden-1-one oxime (2 entities in total)
• Functional Keywords: serine/threonine-protein kinase, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm (By similarity): P04049
• Total number of polymer chains: 2
• Total formula weight: 71608.36

Authors

Hatzivassiliou, G.,Song, K.,Yen, I.,Brandhuber, B.J.,Anderson, D.J.,Alvarado, R.,Ludlam, M.J.,Stokoe, D.,Gloor, S.L.,Vigers, G.P.A.,Morales, T.,Aliagas, I.,Liu, B.,Sideris, S.,Hoeflich, K.P.,Jaiswal, B.S.,Seshagiri, S.,Koeppen, H.,Belvin, M.,Friedman, L.S.,Malek, S. (deposition date: 2010-08-27, release date: 2010-09-15, Last modification date: 2023-09-06)

• Primary citation: Hatzivassiliou, G.,Song, K.,Yen, I.,Brandhuber, B.J.,Anderson, D.J.,Alvarado, R.,Ludlam, M.J.,Stokoe, D.,Gloor, S.L.,Vigers, G.,Morales, T.,Aliagas, I.,Liu, B.,Sideris, S.,Hoeflich, K.P.,Jaiswal, B.S.,Seshagiri, S.,Koeppen, H.,Belvin, M.,Friedman, L.S.,Malek, S.; RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth.; Nature, 464:431-435, 2010; PubMed: 20130576; DOI: 10.1038/nature08833

Experimental method

X-RAY DIFFRACTION (4 Å)