Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

3N3K

The catalytic domain of USP8 in complex with a USP8 specific inhibitor

Summary for 3N3K
Entry DOI10.2210/pdb3n3k/pdb
Related1WHB 2A9U 2FZP 2GFO
DescriptorUbiquitin carboxyl-terminal hydrolase 8, Ubiquitin, ZINC ION, ... (4 entities in total)
Functional Keywordshydrolase, protease, thiol protease, ubl conjugation pathway, deubiquitinating enzyme, dub, zinc ribbon, inhibitor, ubiquitin, isopeptide bond, nucleus, phosphoprotein, structural genomics, structural genomics consortium, sgc
Biological sourceHomo sapiens (human)
More
Cellular locationCytoplasm : P40818
Total number of polymer chains2
Total formula weight54751.48
Authors
Primary citationErnst, A.,Avvakumov, G.,Tong, J.,Fan, Y.,Zhao, Y.,Alberts, P.,Persaud, A.,Walker, J.R.,Neculai, A.M.,Neculai, D.,Vorobyov, A.,Garg, P.,Beatty, L.,Chan, P.K.,Juang, Y.C.,Landry, M.C.,Yeh, C.,Zeqiraj, E.,Karamboulas, K.,Allali-Hassani, A.,Vedadi, M.,Tyers, M.,Moffat, J.,Sicheri, F.,Pelletier, L.,Durocher, D.,Raught, B.,Rotin, D.,Yang, J.,Moran, M.F.,Dhe-Paganon, S.,Sidhu, S.S.
A strategy for modulation of enzymes in the ubiquitin system.
Science, 339:590-595, 2013
Cited by
PubMed: 23287719
DOI: 10.1126/science.1230161
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.6 Å)
Structure validation

217705

数据于2024-03-27公开中

PDB statisticsPDBj update infoContact PDBjnumon