3N3K
The catalytic domain of USP8 in complex with a USP8 specific inhibitor
Summary for 3N3K
Entry DOI | 10.2210/pdb3n3k/pdb |
Related | 1WHB 2A9U 2FZP 2GFO |
Descriptor | Ubiquitin carboxyl-terminal hydrolase 8, Ubiquitin, ZINC ION, ... (4 entities in total) |
Functional Keywords | hydrolase, protease, thiol protease, ubl conjugation pathway, deubiquitinating enzyme, dub, zinc ribbon, inhibitor, ubiquitin, isopeptide bond, nucleus, phosphoprotein, structural genomics, structural genomics consortium, sgc |
Biological source | Homo sapiens (human) More |
Cellular location | Cytoplasm : P40818 |
Total number of polymer chains | 2 |
Total formula weight | 54751.48 |
Authors | Walker, J.R.,Avvakumov, G.V.,Xue, S.,Li, Y.,Allali-Hassani, A.,Lam, R.,Ernst, A.,Sidhu, S.,Weigelt, J.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,Bochkarev, A.,Dhe-Paganon, S.,Structural Genomics Consortium,Structural Genomics Consortium (SGC) (deposition date: 2010-05-20, release date: 2010-06-23, Last modification date: 2023-09-06) |
Primary citation | Ernst, A.,Avvakumov, G.,Tong, J.,Fan, Y.,Zhao, Y.,Alberts, P.,Persaud, A.,Walker, J.R.,Neculai, A.M.,Neculai, D.,Vorobyov, A.,Garg, P.,Beatty, L.,Chan, P.K.,Juang, Y.C.,Landry, M.C.,Yeh, C.,Zeqiraj, E.,Karamboulas, K.,Allali-Hassani, A.,Vedadi, M.,Tyers, M.,Moffat, J.,Sicheri, F.,Pelletier, L.,Durocher, D.,Raught, B.,Rotin, D.,Yang, J.,Moran, M.F.,Dhe-Paganon, S.,Sidhu, S.S. A strategy for modulation of enzymes in the ubiquitin system. Science, 339:590-595, 2013 Cited by PubMed: 23287719DOI: 10.1126/science.1230161 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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