3MVM

P38 Alpha Map Kinase complexed with pyrrolotriazine inhibitor 7V

Summary for 3MVM

• Entry DOI: 10.2210/pdb3mvm/pdb
• Related: 3MVL
• Descriptor: Mitogen-activated protein kinase 14, 4-{[5-(isoxazol-3-ylcarbamoyl)-2-methylphenyl]amino}-5-methyl-N-propylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamide (3 entities in total)
• Functional Keywords: serine/threonine-protein kinase, kinase, transferase, p38 map kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm (By similarity): Q16539
• Total number of polymer chains: 2
• Total formula weight: 85076.93

Authors

Sack, J.S. (deposition date: 2010-05-04, release date: 2010-10-13, Last modification date: 2024-02-21)

• Primary citation: Liu, C.,Lin, J.,Wrobleski, S.T.,Lin, S.,Hynes, J.,Wu, H.,Dyckman, A.J.,Li, T.,Wityak, J.,Gillooly, K.M.,Pitt, S.,Shen, D.R.,Zhang, R.F.,McIntyre, K.W.,Salter-Cid, L.,Shuster, D.J.,Zhang, H.,Marathe, P.H.,Doweyko, A.M.,Sack, J.S.,Kiefer, S.E.,Kish, K.F.,Newitt, J.A.,McKinnon, M.,Dodd, J.H.,Barrish, J.C.,Schieven, G.L.,Leftheris, K.; Discovery of 4-(5-(Cyclopropylcarbamoyl)-2-Methylphenylamino)-5-Methyl-Npropylpyrrolo[1,2-F][1,2,4] Triazine-6-Carboxamide (Bms-582949), a Clinical P38? Map Kinase Inhibitor for the Treatment of Inflammatory Diseases; J.Med.Chem., 53:6629-6639, 2010; PubMed: 20804198; DOI: 10.1021/jm100540x

Experimental method

X-RAY DIFFRACTION (2 Å)