3ML4

Crystal structure of a complex between Dok7 PH-PTB and the MuSK juxtamembrane region

Summary for 3ML4

Entry DOI	10.2210/pdb3ml4/pdb
Descriptor	Protein Dok-7, Muscle, skeletal receptor tyrosine-protein kinase (3 entities in total)
Functional Keywords	tyrosine phosphorylation, adapter protein, dimerization, signaling protein
Biological source	Mus musculus (mouse) More
Cellular location	Cell membrane; Peripheral membrane protein: Q18PE0 Membrane; Single-pass type I membrane protein (Potential): Q61006
Total number of polymer chains	8
Total formula weight	107416.77
Authors	Bergamin, E.,Hubbard, S.R. (deposition date: 2010-04-16, release date: 2010-07-14, Last modification date: 2011-07-13)
Primary citation	Bergamin, E.,Hallock, P.T.,Burden, S.J.,Hubbard, S.R. The Cytoplasmic Adaptor Protein Dok7 Activates the Receptor Tyrosine Kinase MuSK via Dimerization. Mol.Cell, 39:100-109, 2010 Cited by PubMed: 20603078 DOI: 10.1016/j.molcel.2010.06.007 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation