3MJY
Crystal structure of dihydroorotate dehydrogenase from Leishmania major in complex with 5-Aminoorotic acid
Summary for 3MJY
| Entry DOI | 10.2210/pdb3mjy/pdb |
| Related | 3C3N 3GYE 3MHU |
| Descriptor | Dihydroorotate dehydrogenase, FLAVIN MONONUCLEOTIDE, 5-amino-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid, ... (6 entities in total) |
| Functional Keywords | dihydroorotate dehydrogenase, pyrd, oxidoreductase |
| Biological source | Leishmania major |
| Total number of polymer chains | 2 |
| Total formula weight | 76492.89 |
| Authors | Pinheiro, M.P.,Rocha, J.R.,Cheleski, J.,Montanari, C.A.,Nonato, M.C. (deposition date: 2010-04-13, release date: 2011-02-23, Last modification date: 2023-09-06) |
| Primary citation | Cheleski, J.,Rocha, J.R.,Pinheiro, M.P.,Wiggers, H.J.,da Silva, A.B.,Nonato, M.C.,Montanari, C.A. Novel insights for dihydroorotate dehydrogenase class 1A inhibitors discovery. Eur.J.Med.Chem., 45:5899-5909, 2010 Cited by PubMed: 20965617DOI: 10.1016/j.ejmech.2010.09.055 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.96 Å) |
Structure validation
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