3M5E
Crystal structure of human carbonic anhydrase isozyme II with 4-{[N-(6-chloro-5-formyl-2-methylthiopyrimidin-4-yl)amino]methyl}benzenesulfonamide
Summary for 3M5E
Entry DOI | 10.2210/pdb3m5e/pdb |
Related | 3M2N 3M3X 3M40 3MHI 3MHL 3MHM 3MHO |
Descriptor | Carbonic anhydrase 2, ZINC ION, DIMETHYL SULFOXIDE, ... (5 entities in total) |
Functional Keywords | drug design, carbonic anhydrase, sulfonamide, metal-binding, lyase-lyase inhibitor complex, lyase/lyase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm : P00918 |
Total number of polymer chains | 1 |
Total formula weight | 29805.45 |
Authors | Grazulis, S.,Manakova, E.,Golovenko, D. (deposition date: 2010-03-12, release date: 2010-10-20, Last modification date: 2023-11-01) |
Primary citation | Sudzius, J.,Baranauskiene, L.,Golovenko, D.,Matuliene, J.,Michailoviene, V.,Torresan, J.,Jachno, J.,Sukackaite, R.,Manakova, E.,Grazulis, S.,Tumkevicius, S.,Matulis, D. 4-[N-(Substituted 4-pyrimidinyl)amino]benzenesulfonamides as inhibitors of carbonic anhydrase isozymes I, II, VII, and XIII Bioorg.Med.Chem., 18:7413-7421, 2010 Cited by PubMed: 20889345DOI: 10.1016/j.bmc.2010.09.011 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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