3M2N

Crystal structure of human carbonic anhydrase isozyme II with 4-{2-[N-(6-chloro-5-nitropyrimidin-4-yl)amino]ethyl}benzenesulfonamide

Summary for 3M2N

Entry DOI	10.2210/pdb3m2n/pdb
Related	3M3X 3M40 3M5E 3MHI 3MHL 3MHM 3MHO
Descriptor	Carbonic anhydrase 2, 4-{2-[(6-chloro-5-nitropyrimidin-4-yl)amino]ethyl}benzenesulfonamide, ZINC ION, ... (6 entities in total)
Functional Keywords	drug design, carbonic anhydrase, sulfonamide, lyase, metal-binding, lyase-lyase inhibitor complex, lyase/lyase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm : P00918
Total number of polymer chains	1
Total formula weight	30031.68
Authors	Grazulis, S.,Manakova, E.,Golovenko, D. (deposition date: 2010-03-08, release date: 2011-02-16, Last modification date: 2023-11-01)
Primary citation	Capkauskaite, E.,Zubriene, A.,Baranauskiene, L.,Tamulaitiene, G.,Manakova, E.,Kairys, V.,Grazulis, S.,Tumkevicius, S.,Matulis, D. Design of [(2-pyrimidinylthio)acetyl]benzenesulfonamides as inhibitors of human carbonic anhydrases. Eur.J.Med.Chem., 51:259-270, 2012 Cited by PubMed: 22440859 DOI: 10.1016/j.ejmech.2012.02.050 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.65 Å)

Structure validation