3LZU
Crystal Structure of a Nelfinavir Resistant HIV-1 CRF01_AE Protease variant (N88S) in Complex with the Protease Inhibitor Darunavir.
Summary for 3LZU
Entry DOI | 10.2210/pdb3lzu/pdb |
Related | 3LZS 3LZV |
Descriptor | HIV-1 protease, ACETATE ION, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, ... (4 entities in total) |
Functional Keywords | hiv-1 protease, non-b clades, crf01_ae, inhibitor resistance, aids, aspartyl protease, hydrolase |
Biological source | Human immunodeficiency virus 1 |
Total number of polymer chains | 2 |
Total formula weight | 22322.43 |
Authors | Schiffer, C.A.,Bandaranayake, R.M. (deposition date: 2010-03-01, release date: 2010-08-11, Last modification date: 2023-09-06) |
Primary citation | Bandaranayake, R.M.,Kolli, M.,King, N.M.,Nalivaika, E.A.,Heroux, A.,Kakizawa, J.,Sugiura, W.,Schiffer, C.A. The Effect of Clade-Specific Sequence Polymorphisms on HIV-1 Protease Activity and Inhibitor Resistance Pathways. J.Virol., 84:9995-10003, 2010 Cited by PubMed: 20660190DOI: 10.1128/JVI.00505-10 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.76 Å) |
Structure validation
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