3LP3
p15 HIV RNaseH domain with inhibitor MK3
Summary for 3LP3
Entry DOI | 10.2210/pdb3lp3/pdb |
Related | 3LP0 3LP1 3LP2 |
Descriptor | p15, MANGANESE (II) ION, 3-[4-(diethylamino)phenoxy]-6-(ethoxycarbonyl)-5,8-dihydroxy-7-oxo-7,8-dihydro-1,8-naphthyridin-1-ium, ... (4 entities in total) |
Functional Keywords | reverse transcriptase, rnase h, hiv, aids, capsid maturation, dna integration, dna-directed dna polymerase, endonuclease, host cytoplasm, host nucleus, multifunctional enzyme, rna-binding, rna-directed dna polymerase, viral nucleoprotein, virion, viral protein |
Biological source | Human immunodeficiency virus type 1 (HIV-1) |
Cellular location | Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P0C6F2 |
Total number of polymer chains | 2 |
Total formula weight | 31397.12 |
Authors | Yan, Y.,Munshi, S.K.,Prasad, G.S.,Su, H.P. (deposition date: 2010-02-04, release date: 2010-06-09, Last modification date: 2024-02-21) |
Primary citation | Su, H.P.,Yan, Y.,Prasad, G.S.,Smith, R.F.,Daniels, C.L.,Abeywickrema, P.D.,Reid, J.C.,Loughran, H.M.,Kornienko, M.,Sharma, S.,Grobler, J.A.,Xu, B.,Sardana, V.,Allison, T.J.,Williams, P.D.,Darke, P.L.,Hazuda, D.J.,Munshi, S. Structural basis for the inhibition of RNase H activity of HIV-1 reverse transcriptase by RNase H active site-directed inhibitors. J.Virol., 84:7625-7633, 2010 Cited by PubMed: 20484498DOI: 10.1128/JVI.00353-10 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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