3LON

HCV NS3-4a protease domain with ketoamide inhibitor narlaprevir

Summary for 3LON

• Entry DOI: 10.2210/pdb3lon/pdb
• Descriptor: Genome polyprotein, KK-NS4a(21-39)-KK, ZINC ION, ... (6 entities in total)
• Functional Keywords: hepatitis c virus, ns3 protease domain, serine protease, macrocyclic ketoamide inhibitor, hydrolase, atp-binding, capsid protein, envelope protein, helicase, host membrane, membrane, nucleotide-binding, rna replication, transmembrane, virion, viral protein, viral protein-inhibitor complex, viral protein/inhibitor
• Biological source: Hepatitis C virus subtype 1a; More
• Total number of polymer chains: 4
• Total formula weight: 48173.46

Authors

Prongay, A.J. (deposition date: 2010-02-04, release date: 2011-01-19, Last modification date: 2024-04-03)

• Primary citation: Arasappan, A.,Bennett, F.,Bogen, S.L.,Blackman, M.,Chen, K.,Hendrata, S.,Huang, Y.,Huelgas, R.M.,Nair, L.,Padilla, A.I.,Pan, W.,Pike, R.,Pinto, P.,Ruan, S.,Sannigrahi, M.,Velaquez, F.,Vibulbhan, B.,Wu, W.,Yang, W.,Saksena, A.K.,Girijavallabhan, V.,Shih, N.Y.,Kong, J.,Meng, T.,Jin, Y.,Wong, J.,McNamara, P.,Prongay, A.,Madison, V.,Piwinski, J.J.,Cheng, K.C.,Morrison, R.,Malcolm, B.,Tong, X.,Ralston, R.,Njoroge, F.G.; Candidate selection and preclinical evaluation culminating in the discovery of Narlaprevir (SCH 900518): A potent, selective and orally efficacious second generation HCV NS3 serine protease inhibitor; To be Published,

Experimental method

X-RAY DIFFRACTION (2.2 Å)