3LJT

Crystal Structure of the Catalytic Domain of ADAMTS-5 in Complex with an Amino-2-indanol compound

Summary for 3LJT

Entry DOI	10.2210/pdb3ljt/pdb
Related	3HY9 3HYG 3LJZ
Descriptor	A disintegrin and metalloproteinase with thrombospondin motifs 5, (2R)-2-[4-(1,3-benzodioxol-5-yl)benzyl]-N~4~-hydroxy-N~1~-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]butanediamide, 1,2-ETHANEDIOL, ... (6 entities in total)
Functional Keywords	alpha/beta structure, central five stranded beta-sheet, cleavage on pair of basic residues, disulfide bond, extracellular matrix, glycoprotein, metal-binding, metalloprotease, protease, secreted, zymogen, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Secreted, extracellular space, extracellular matrix : Q9UNA0
Total number of polymer chains	1
Total formula weight	24827.43
Authors	Shieh, H.-S.,Williams, J.M.,Caspers, N. (deposition date: 2010-01-26, release date: 2010-03-31, Last modification date: 2023-09-06)
Primary citation	Shieh, H.S.,Tomasselli, A.G.,Mathis, K.J.,Schnute, M.E.,Woodard, S.S.,Caspers, N.,Williams, J.M.,Kiefer, J.R.,Munie, G.,Wittwer, A.,Malfait, A.M.,Tortorella, M.D. Structure analysis reveals the flexibility of the ADAMTS-5 active site. Protein Sci., 20:735-744, 2011 Cited by PubMed: 21370305 DOI: 10.1002/pro.606 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation