3LHG

Bace1 in complex with the aminohydantoin Compound 4g

Summary for 3LHG

Entry DOI	10.2210/pdb3lhg/pdb
Descriptor	Beta-secretase 1, (5S)-2-amino-5-(2',5'-difluorobiphenyl-3-yl)-3-methyl-5-pyridin-4-yl-3,5-dihydro-4H-imidazol-4-one (3 entities in total)
Functional Keywords	inhibitor, aminohydantoin, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Membrane; Single-pass type I membrane protein: P56817
Total number of polymer chains	1
Total formula weight	46819.36
Authors	Olland, A.M. (deposition date: 2010-01-22, release date: 2010-04-21, Last modification date: 2023-09-06)
Primary citation	Zhou, P.,Li, Y.,Fan, Y.,Wang, Z.,Chopra, R.,Olland, A.,Hu, Y.,Magolda, R.L.,Pangalos, M.,Reinhart, P.H.,Turner, M.J.,Bard, J.,Malamas, M.S.,Robichaud, A.J. Pyridinyl aminohydantoins as small molecule BACE1 inhibitors. Bioorg.Med.Chem.Lett., 20:2326-2329, 2010 Cited by PubMed: 20202842 DOI: 10.1016/j.bmcl.2010.01.136 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation